**Now it is important** to not have the same FQDN in `myhostname` as you use for your dockerized mailcow. Check your local (non-Docker) Postfix' main.cf for `myhostname` and set it to something different, for example `local.my.fqdn.tld`.
"172.22.1.1" is the mailcow created network gateway in Docker.
Relaying over this interface is necessary (instead of - for example - relaying directly over ${MAILCOW_HOSTNAME}) to relay over a known internal network.